Susceptibility to IOP is believed to be dependent on the morphology, the biomechanical properties, and the collagen fiber organization of ONH connective tissues (lamina and sclera). However, axonal damage can occur, even within the normal range of IOP, if the optic nerve head (ONH) is susceptible to a given level of IOP-related stress/strain. In addition, our group recently demonstrated greater LC curvature in primary open-angle glaucoma (POAG) eyes compared to healthy control by using swept-source OCT. It has been well documented by enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) that the lamina cribrosa (LC) displaces posteriorly in glaucomatous eyes compared to healthy control. The biomechanical theory suggests that the pathogenesis of glaucoma involves progressive axonal damage consequent upon IOP-related stress (force/cross sectional area) and strain (local deformation). The funding organizations had no role in the design or conduct of this research.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by a grant of NUS Young Investigator Award (NUSYIA_FY13_P03, R-397-000-174-133). Received: MaAccepted: AugPublished: September 9, 2016Ĭopyright: © 2016 Kim et al. RNFL, retinal nerve fiber layer SD-OCT, spectral-domain optical coherence tomography.Citation: Kim YW, Jeoung JW, Girard MJA, Mari JM, Park KH (2016) Positional and Curvature Difference of Lamina Cribrosa According to the Baseline Intraocular Pressure in Primary Open-Angle Glaucoma: A Swept-Source Optical Coherence Tomography (SS-OCT) Study. However, validity of RNFL thickness measurement can be limited by poor automated segmentation in marked swelling optic disc. On the contrary, (G) swelling optic disc RNFL thickness is well above normal range. (H) Measurement of RNFL is within normal range for age. (G,H) Comparison of RNFL thickness to normal range for patient age (green area). (C) Cross-sectional and (E) circular tomogram of swelling optic disc by SD-OCT demonstrates marked thickening of RNFL, area between red and purple line, compares to (D,F) tomograms from normal optic disc. Also depicting in fundus photography are (white dashed line in A, B) plane of cross-sectional tomogram of RNFL and (green circular dashed line in A, B) plane of circular tomogram of peripapillary RNFL. (A) fundus photography shows marked swelling of optic disc with obscuration of peripapillary major retinal vessels in papilledema compares to (B) normal optic disc with sharp margin. Panel of images demonstrates comparison between papilledema and normal optic disc by fundus photography and SD-OCT of RNFL. Optical coherence tomography (OCT) idiopathic intracranial hypertension (IIH) pseudotumor cerebri. ![]() This review will discuss how OCT can be used to assess a patient with IIH, both before and after treatment, along with its limitations and future applications. OCT is a promising modality for clinical and scientific evaluation of IIH as it is a noninvasive and practical tool to obtain in depth images. Numerous studies have used OCT in IIH as well, and they have shown that certain retinal layers and the ONH change in thickness and shape in both the short and long term with intracranial pressure changes. OCT can create 2-dimensional and 3-dimensional high definition images of the retina of the ONH and has been used to study various conditions such as glaucoma and multiple sclerosis. In order to find other biomarkers of disease, researchers are using imaging modalities such as optical coherence tomography (OCT) to observe microscopic changes in the eye in this condition. Physicians are currently limited in their ability to monitor and manage this condition, as clinical symptoms and exam findings are often delayed in response to changes in intracranial pressure. Idiopathic intracranial hypertension (IIH) is a condition in which elevated pressure in the cerebrospinal fluid can lead to optic nerve head (ONH) dysfunction and subsequent visual impairment.
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